The Histone Acetyltransferase NCOAT Contains a Zinc Finger-like Motif Involved in Substrate Recognition
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چکیده
منابع مشابه
The histone H4 acetyltransferase MOF uses a C2HC zinc finger for substrate recognition.
Site-specific acetylation of histone H4 by MOF is central to establishing the hyperactive male X chromosome in Drosophila. MOF belongs to the MYST family of histone acetyltransferases (HATs) characterized by an unusual C2HC-type zinc finger close to their HAT domains. The function of these rare zinc fingers is unknown. We found that this domain is essential for HAT activity, in addition to the ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m510485200